HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 29448Generated: October 26, 2026
2-Amino-4-(trifluoromethyl)benzenethiol → 5-Trifluoromethyl-benzothiazole-2-carboxylic acid ethyl ester
https://huagongshe.com/reaction/29448
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Amino-4-(trifluoromethyl)benzenethiol | HCID 88042 | — |
| Reactant | Ethyl 2,2,2-triethoxyacetate | HCID 5090273 | — |
| Product | 5-Trifluoromethyl-benzothiazole-2-carboxylic acid ethyl ester | HCID 55189808 | — |
Reaction Steps
To 2-amino-4-trifluoromethyl-benzenethiol (0.7 g) was added ethyl triethoxyacetate (3 eq). The mixture was stirred at 110° C. overnight. The reaction mixture was cooled and triturated with hexane. Filtration gave 460 mg of 5-trifluoromethyl-benzothiazole-2-carboxylic acid ethyl ester as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07420001B2 |
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| Source dataset | uspto-grants-2008_09 |
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| ORD ID | ord-0b562ebc862241489a596e1f9fcc353b |
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| Source note | uspto-grants-2008_09 |
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