Trifluoroacetic acid methylene chloride → 3-Methyl-4-(pyridin-3-ylmethoxy)-benzofuran-2-carboxylic acid

HRID 29485

Reaction equation

HRID 29485 reaction equation
C([O:5][C:6]([C:8]1[O:9][C:10]2[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH2:19][C:20]3[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=3)[C:11]=2[C:12]=1[CH3:13])=[O:7])(C)(C)C.C(O)(C(F)(F)F)=O.C(Cl)Cl>>[CH3:13][C:12]1[C:11]2[C:14]([O:18][CH2:19][C:20]3[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=3)=[CH:15][CH:16]=[CH:17][C:10]=2[O:9][C:8]=1[C:6]([OH:7])=[O:5]

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 687169743-Methyl-4-(pyridin-3-ylmethoxy)-benzofuran-2-carboxylic acid t-butyl ester

Product 1

HCID 687166823-Methyl-4-(pyridin-3-ylmethoxy)-benzofuran-2-carboxylic acid

Procedure

The 3-methyl-4-(pyridin-3-ylmethoxy)-benzofuran-2-carboxylic acid t-butyl ester was dissolved into a 40% TFA/methylene chloride solution, and stirred at room temperature for 4 hours. Evaporation of the solvent gave 3-methyl-4-(pyridin-3-ylmethoxy)-benzofuran-2-carboxylic acid in quantitative yield.

Workup

  1. customEvaporation of the solvent

Sources & evidence

ORD record
ord-12efaa82323c42619673e614c284d259
Source dataset
uspto-grants-2008_09
Patent number
US07420001B2

Linked notes

Loading…