Acetic Acid → 2-Furan-2-yl-6-[4-(2,4,6-trifluoro-benzyl)-piperazin-1-yl]-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamine

HRID 295250

Reaction equation

HRID 295250 reaction equation
[C:33]([O:34][BH-:35]([O:36][C:37](=[O:38])[CH3:39])[O:40][C:41](=[O:42])[CH3:43])(=[O:44])[CH3:45].[C:51]([O:52][C:53]([N:54]1[CH2:55][CH2:56][N:57]([c:58]2[n:59][c:60]3[c:61]([n:62][cH:63]2)[n:64][cH:65][n:66]([CH3:67])[c:68]3=[O:69])[CH2:70][CH2:71]1)=[O:72])([CH3:73])([CH3:74])[CH3:75].[CH3:47][C:48](=[O:49])[OH:50].[F:22][c:23]1[c:24]([CH:25]=[O:26])[c:27]([F:32])[cH:28][c:29]([F:31])[cH:30]1.[Na+:46].[o:1]1[c:2](-[c:6]2[n:7][n:8]3[c:9]([c:10]([NH2:20])[n:11][c:12]([N:14]4[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]4)[cH:13]3)[n:21]2)[cH:3][cH:4][cH:5]1>>[o:1]1[c:2](-[c:6]2[n:7][n:8]3[c:9]([c:10]([NH2:20])[n:11][c:12]([N:14]4[CH2:15][CH2:16][N:17]([CH2:25][c:24]5[c:23]([F:22])[cH:30][c:29]([F:31])[cH:28][c:27]5[F:32])[CH2:18][CH2:19]4)[cH:13]3)[n:21]2)[cH:3][cH:4][cH:5]1

Participants

7

Reactant 6

HCID 176Acetic AcidHCID 923Sodium ionHCID 5218452,4,6-TrifluorobenzaldehydeHCID 2724942TriacetoxyborohydrideHCID 111619332-Furan-2-yl-6-piperazin-1-yl-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamineHCID 66745135Tert-butyl 4-(3-methyl-4-oxo-3,4-dihydropteridin-6-yl)piperazine-1-carboxylate

Product 1

HCID 111778682-Furan-2-yl-6-[4-(2,4,6-trifluoro-benzyl)-piperazin-1-yl]-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamine

Sources & evidence

ORD record
ord-5a36b3cab087446a91e94abe7c75a400
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Linked notes

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