Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 29549Generated: October 24, 2026

4-t-Butylbenzenesulfonyl chloride → 4-tert-butyl-N-(4-chloro-2-isonicotinoylphenyl)benzenesulfonamide

https://huagongshe.com/en/reaction/29549

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-t-Butylbenzenesulfonyl chlorideHCID 139882—
Reactant(2-Amino-5-chlorophenyl)-pyridin-4-yl methanoneHCID 10214538—
Product4-tert-butyl-N-(4-chloro-2-isonicotinoylphenyl)benzenesulfonamideHCID 9823937—

Reaction Steps

The title compound was prepared according to the general procedure for the synthesis of N-Aryl-benzenesulfonamides previously described using 116 mg of (2-Amino-5-chloro-phenyl)-pyridin-4-yl-methanone and 116 mg of 4-tert-Butyl-benzenesulfonyl chloride. 1H-NMR (400 MHz, CDCl3): δ 1.25 (s, 9H), 7.02 (d, 1H, J=8.4 Hz). 7.44 (m, 3H), 7.66 (d, 2H, J=8.4), 7.79 (d, 1H, J=2.4 Hz), 8.11 (d, 2H, J=6.4), 8.88 d, 2H, J=6.0 Hz), 10.51 (s, 1H). MS: m/z 429.9 (M++1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07420055B2
Source datasetuspto-grants-2008_09
ORD IDord-572e5d3d737d4ee196c424791109b989
Source noteuspto-grants-2008_09