Sodium Ion → 2-(4-methoxy-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-5-methylbenzonitrile

Reaction equation

[Br:13][c:14]1[c:15]([C:16]#[N:17])[cH:18][c:19]([CH3:22])[cH:20][cH:21]1.[CH3:1][O:2][c:3]1[c:4]2[c:5]([n:6][cH:7][n:8]1)[CH2:9][CH2:10][NH:11][CH2:12]2.[CH3:23][C:24]([CH3:25])([O-:26])[CH3:27].[Na+:28]>>[CH3:1][O:2][c:3]1[c:4]2[c:5]([n:6][cH:7][n:8]1)[CH2:9][CH2:10][N:11]([c:14]1[c:15]([C:16]#[N:17])[cH:18][c:19]([CH3:22])[cH:20][cH:21]1)[CH2:12]2

Participants

Reactant 4

HCID 923Sodium Ion

HCID 45749132-Methylpropan-2-olate

HCID 125572012-Bromo-5-methylbenzonitrile

HCID 509892144-methoxy-5H,6H,7H,8H-pyrido[4,3-d]pyrimidine

Product 1

HCID 598407122-(4-methoxy-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-5-methylbenzonitrile

Sources & evidence

ORD record: ord-e5e0382ea0824dbf9e9fd83192ed9a65
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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