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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 29581Generated: October 26, 2026

4-Ethylbenzene-1-sulfonyl chloride → N-[4-Bromo-2-(pyridine-4-carbonyl)-phenyl]4-ethyl-benzenesulfonamide

https://huagongshe.com/reaction/29581

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Ethylbenzene-1-sulfonyl chlorideHCID 570959—
Reactant(2-Amino-5-bromophenyl)(pyridin-4-yl)methanoneHCID 13549724—
ProductN-[4-Bromo-2-(pyridine-4-carbonyl)-phenyl]4-ethyl-benzenesulfonamideHCID 10366214—

Reaction Steps

The title compound was prepared according to the general procedure for the synthesis of N-Aryl-benzenesulfonamides previously described using 138 mg of (2-Amino-5-bromo-phenyl)-pyridin-4-yl-methanone and 102 mg of 4-ethyl-benzenesulfonyl chloride. 1H-NMR (400 MHz, CDCl3): δ 1.19 (t, 3H, J=7.6 Hz), 2.62 (q, 2H, J=7.6 Hz), 7.20 (d, 2H, J=8.8 Hz, 7.38 (m, 3H), 7.65-7.72 (m, 4H), 8.81 (d, 2H, 6.4 Hz), 10.06 (s,1H). MS: m/z 446.0 (M++1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07420055B2
Source datasetuspto-grants-2008_09
ORD IDord-553310262acb435cbe0610d6465d0532
Source noteuspto-grants-2008_09