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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 29594Generated: October 27, 2026

4-Methanesulfonylbenzene-1-sulfonyl chloride → N-[4-Chloro-2-(2-methyl-pyridine-4-carbonyl)-phenyl]-4-methanesulfonyl-benzenesulfonamide

https://huagongshe.com/reaction/29594

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methanesulfonylbenzene-1-sulfonyl chlorideHCID 2735182—
Reactant(2-Amino-5-chloro-phenyl)-(2-methyl-pyridin-4-yl)-methanoneHCID 22327293—
ProductN-[4-Chloro-2-(2-methyl-pyridine-4-carbonyl)-phenyl]-4-methanesulfonyl-benzenesulfonamideHCID 10253911—

Reaction Steps

The title compound was prepared according to the general procedure for the synthesis of N-Aryl-benzenesulfonamides previously described using (2-Amino-5-chloro-phenyl)-(2-methyl-pyridin-4-yl)-methanone and 4-methanesulfonyl-benzenesulfonyl chloride and purified by HPLC. 1H NMR (CDCl3) δ 10.38 (s, 1H) 8.64 (s 1H) 7.95 (s, 4H) 7.72 (s, 1H) 7.51 (s, 1H) 7.31 (s, 1H) 7.11 (s, 1H) 6.99 (s, 1H) 3.04 (s, 3H) 2.64 (s, 3H). MS: (ES) m/z=464.9 (M++1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07420055B2
Source datasetuspto-grants-2008_09
ORD IDord-a6f7ffa510fb470f9aed443eb25e7e83
Source noteuspto-grants-2008_09