Reaction equation
C[O:2][C:3](=[O:15])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12]Br)=[CH:6][C:5]=1[OH:14].[C:16]1([C:22](=[N:24][OH:25])[CH3:23])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[OH:14][C:5]1[CH:6]=[C:7]([O:10][CH2:11][CH2:12][O:25][N:24]=[C:22]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH3:23])[CH:8]=[CH:9][C:4]=1[C:3]([OH:2])=[O:15]Participants
3
Procedure
2-Hydroxy-4-[2-({[1-phenylethylidene]amino}oxy)ethoxy]benzoic acid was prepared as a white solid (0.712 g, 27%) from 4-(2-bromo-ethoxy)-2-hydroxy-benzoic acid methyl ester and 1-phenyl-ethanone oxime using a procedure similar to that of step 1 of example 6. 1H NMR (400 MHz, DMSO-d6); δ 13.60 (bs, 1H), 11.50 (bs, 1H), 7.66 (m, 3H), 7.40 (m, 3H), 6.53 (dd, 1H), 6.52 (s, 1H), 4.44 (t, 2H), 4.32 (t, 2H), 2.18 (m, 2H).
Sources & evidence
- ORD record
- ord-2b347c66c79042b9befe2d13603f1c67
- Source dataset
- uspto-grants-2008_09
- Patent number
- US07420083B2
Linked notes
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