Methanol → 4-{[Tert-butyl(dimethyl)silyl]oxy}-3-fluorocyclohexanol

Reaction equation

[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][CH:9]1[CH2:10][CH:11]([F:23])[CH:12]([O:15][Si:16]([CH3:17])([CH3:18])[C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:13][CH2:14]1.[CH3:24][OH:25].[OH-:26].[OH-:27].[Pd+2:28]>>[OH:8][CH:9]1[CH2:10][CH:11]([F:23])[CH:12]([O:15][Si:16]([CH3:17])([CH3:18])[C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:13][CH2:14]1

Participants

Reactant 4

HCID 887Methanol

HCID 961Hydroxide2×

HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)

HCID 59543150HCID 59543150, compound

Product 1

HCID 595431354-{[Tert-butyl(dimethyl)silyl]oxy}-3-fluorocyclohexanol

Sources & evidence

ORD record: ord-c2373d3b98dc4253812131fcf207465c
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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