HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → Trimethylsilylethoxymethyltetrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Chloromethyl 2-(trimethylsilyl)ethyl ether | HCID 2724271 | — |
| Reactant | HCID 178418441 | HCID 178418441 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Trimethylsilylethoxymethyltetrazole | HCID 178418485 | — |
Reaction Steps
To a Suspension of 1.1 mmol NaH in 5 mL DMF at 0° C. was added a solution of 1.0 mmol tetrazole in 2 mL DMF. After 30 min, trimethylsilylethoxymethylchloride was added and the mixture stirred for 16 h. Extraction and chromatography provided trimethylsilylethoxymethyltetrazole as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05731432 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-dfbffeb92a874b419566deb178159f88 |
| Source note | uspto-grants-1998_03 |