Nitric Acid → N-(5-Chloro-2-hydroxy-3-nitrophenyl)acetamide

HRID 29858

Reaction equation

HRID 29858 reaction equation
S(=O)(=O)(O)O.[Cl:6][C:7]1[CH:8]=[CH:9][C:10]([OH:17])=[C:11]([NH:13][C:14](=[O:16])[CH3:15])[CH:12]=1.[N+:18]([O-])([OH:20])=[O:19]>O>[Cl:6][C:7]1[CH:8]=[C:9]([N+:18]([O-:20])=[O:19])[C:10]([OH:17])=[C:11]([NH:13][C:14](=[O:16])[CH3:15])[CH:12]=1

Participants

5

Reactant 3

HCID 944Nitric Acid2×HCID 1118Sulfuric Acid2×HCID 952582-Acetylamino-4-chlorophenol

Product 1

HCID 22142329N-(5-Chloro-2-hydroxy-3-nitrophenyl)acetamide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
25 °C

Procedure

224.5 g of sulphuric acid (50% w/w) was dissolved in 300 ml of water and cooled to 25° C. while stirring under a mild nitrogen purge. 185.1 g (1 mole) of N-(5-chloro-2-hydroxyphenyl)acetamide prepared according to Example 1a was added to the diluted sulphuric acid and mixed intensively. 4 ml of nitric acid 65% w/w was added to the foam formed on top of the reaction mixture at low stirring speed. The stirring speed was increased and 75 ml of nitric acid 65% w/w was added in 45 minutes, while maintaining the temperature between 23 and 26° C. The mixture was stirred vigorously for an additional 1 hour at 23-26° C. Then the mixture was cooled to 0-5° C. and vigorously stirred at this temperature for 1 hour. The solid was filtered off quickly, washed three times with 300 ml of cold water, sucked for at least 30 minutes and dried at 50° C. and 100 mbar under a gentle nitrogen stream till dry.

Workup

  1. custompurge
  2. additionmixed intensively
  3. customformed on top of the reaction mixture at low stirring speed
  4. temperatureThe stirring speed was increased
  5. temperaturewhile maintaining the temperature between 23 and 26° C
  6. stirringThe mixture was stirred vigorously for an additional 1 hour at 23-26° C
  7. temperatureThen the mixture was cooled to 0-5° C.
  8. stirringvigorously stirred at this temperature for 1 hour
  9. filtrationThe solid was filtered off quickly
  10. washwashed three times with 300 ml of cold water
  11. waitsucked for at least 30 minutes
  12. customdried at 50° C.
  13. customtill dry

Sources & evidence

ORD record
ord-ccd13ade850745d4aaf7dc82903a0142
Source dataset
uspto-grants-2008_09
Patent number
US07423040B2

Linked notes

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