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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 29910Generated: October 26, 2026

1-(Bromomethyl)-4-(trifluoromethyl)benzene → 2-(3,5-Dichlorophenyl)-4-isopropyl-6-{[4-(trifluoromethyl)benzyl]oxy}pyrimidine

https://huagongshe.com/reaction/29910

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Bromomethyl)-4-(trifluoromethyl)benzeneHCID 123062—
ReactantHCID 178439458HCID 178439458—
Product2-(3,5-Dichlorophenyl)-4-isopropyl-6-{[4-(trifluoromethyl)benzyl]oxy}pyrimidineHCID 10366005—

Reaction Steps

The title compound was prepared from 2-(3,5-dichloro-phenyl)-6-isopropyl-pyrimidin-4-ol (which was obtained in Intermediate 6) and 4-(trifluoromethyl)benzyl bromide according to Method A; LC retention time 4.57 min; MS: m/z (ESI) 441 (M+H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07423044B2
Source datasetuspto-grants-2008_09
ORD IDord-50b5ce710744452aac637dd3582d1cd2
Source noteuspto-grants-2008_09