p-Bromochlorobenzene → tert-Butyl {4-[(4'-chloro-4-methoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate

HRID 299158

Reaction equation

HRID 299158 reaction equation
[BH:1]([OH:2])[OH:3].[Br:29][c:30]1[cH:31][cH:32][c:33]([Cl:36])[cH:34][cH:35]1.[C:4](=[O:5])([O:6][C:7]([CH3:8])([CH3:9])[CH3:10])[N:11]([CH:12]1[CH2:13][CH2:14][CH:15]([NH:18][CH2:19][c:20]2[cH:21][cH:22][cH:23][cH:24][c:25]2[O:26][CH3:27])[CH2:16][CH2:17]1)[CH3:28]>>[C:4](=[O:5])([O:6][C:7]([CH3:8])([CH3:9])[CH3:10])[N:11]([CH:12]1[CH2:13][CH2:14][CH:15]([NH:18][CH2:19][c:20]2[cH:21][c:22](-[c:30]3[cH:31][cH:32][c:33]([Cl:36])[cH:34][cH:35]3)[cH:23][cH:24][c:25]2[O:26][CH3:27])[CH2:16][CH2:17]1)[CH3:28]

Participants

4

Reactant 3

HCID 7806p-BromochlorobenzeneHCID 61668Boronic AcidHCID 69166809tert-butyl N-[4-[(2-methoxyphenyl)methylamino]cyclohexyl]-N-methylcarbamate

Product 1

HCID 59683614tert-Butyl {4-[(4'-chloro-4-methoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate

Sources & evidence

ORD record
ord-7bba7a38b62c493fa3177f73a80bfbda
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Linked notes

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