2-Thiophenecarbonyl chloride → 5-Methoxy-2-(thiophene-2-carbonyl)benzoic acid

HRID 29930

Reaction equation

HRID 29930 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](Cl)=[O:7].Br[C:10]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][C:11]=1[C:12]([OH:14])=[O:13]>>[CH3:20][O:19][C:16]1[CH:17]=[CH:18][C:10]([C:6]([C:2]2[S:1][CH:5]=[CH:4][CH:3]=2)=[O:7])=[C:11]([CH:15]=1)[C:12]([OH:14])=[O:13]

Participants

3

Reactant 2

HCID 789282-Thiophenecarbonyl chlorideHCID 899062-Bromo-5-methoxybenzoic acid

Product 1

HCID 692129835-Methoxy-2-(thiophene-2-carbonyl)benzoic acid

Procedure

This compound is obtained according to the procedure described in 1.1. by reacting thiophene-2-carboxylic acid chloride and 2-bromo-5-methoxybenzoic acid after halogen-lithium exchange. It is used in crude form in the following reaction.

Workup

  1. customThis compound is obtained
  2. customin the following reaction

Sources & evidence

ORD record
ord-bf6e0b3446874b6d93e4631883a57601
Source dataset
uspto-grants-2008_09
Patent number
US07423030B2

Linked notes

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