Phenylacetyl chloride → 3,5-Dimethoxy-2-(phenylacetyl)benzoic acid

HRID 29966

Reaction equation

HRID 29966 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:10]=[C:11]([O:13][CH3:14])[CH:12]=1)[C:6]([O:8]C)=[O:7].[C:15]1([CH2:21][C:22](Cl)=[O:23])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[CH3:1][O:2][C:3]1[C:4]([C:22](=[O:23])[CH2:21][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:5]([CH:10]=[C:11]([O:13][CH3:14])[CH:12]=1)[C:6]([OH:8])=[O:7]

Participants

3

Reactant 2

HCID 7679Phenylacetyl chlorideHCID 75074Methyl 3,5-Dimethoxybenzoate

Product 1

HCID 692138893,5-Dimethoxy-2-(phenylacetyl)benzoic acid

Procedure

This compound is synthesized by reacting methyl 3,5-dimethoxybenzoate with phenylacetyl chloride via the Friedel-Crafts reaction, followed by saponification of the ester obtained, according to the method described in 2.1. It is used in crude form in the following reaction.

Workup

  1. customThis compound is synthesized
  2. customvia the Friedel-Crafts reaction
  3. customobtained
  4. customin the following reaction

Sources & evidence

ORD record
ord-f474b4227e984e3b8f420708e210bfb8
Source dataset
uspto-grants-2008_09
Patent number
US07423030B2

Linked notes

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