Propionyl chloride → 3,5-Dimethoxy-2-propionylbenzoic acid

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:10]=[C:11]([O:13][CH3:14])[CH:12]=1)[C:6]([O:8]C)=[O:7].[C:15](Cl)(=[O:18])[CH2:16][CH3:17]>>[CH3:1][O:2][C:3]1[C:4]([C:15](=[O:18])[CH2:16][CH3:17])=[C:5]([CH:10]=[C:11]([O:13][CH3:14])[CH:12]=1)[C:6]([OH:8])=[O:7]

Participants

Reactant 2

HCID 62324Propionyl chloride

HCID 75074Methyl 3,5-Dimethoxybenzoate

Product 1

HCID 692142953,5-Dimethoxy-2-propionylbenzoic acid

Procedure

This compound is synthesized by reacting methyl 3,5-dimethoxybenzoate with propionyl chloride via the Friedel-Crafts reaction, followed by saponification of the ester obtained, according to the method described in 2.1. It is used in crude form in the following reaction.

Workup

customThis compound is synthesized
customvia the Friedel-Crafts reaction
customobtained
customin the following reaction

Sources & evidence

ORD record: ord-9378b4ce2200480e812cad8e537d91d2
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07423030B2

Reaction notes

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