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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 29974Generated: October 26, 2026

2-Bromo-5-methoxybenzoic acid → 5-Methoxy-2-(methoxyacetyl)benzoic acid

https://huagongshe.com/reaction/29974

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Bromo-5-methoxybenzoic acidHCID 89906—
ReactantN,2-dimethoxy-N-methylacetamideHCID 14872187—
ReactantButyllithiumHCID 178418339—
Product5-Methoxy-2-(methoxyacetyl)benzoic acidHCID 57691641—

Reaction Steps

This compound is synthesized according to the method described in 3.2. by reacting 2-bromo-5-methoxybenzoic acid pretreated with n-butyllithium with 2,N-dimethoxy-N-methylacetamide. It is used in crude form in the following reaction.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07423030B2
Source datasetuspto-grants-2008_09
ORD IDord-8118043a55e74abf81bf8225208db8d1
Source noteuspto-grants-2008_09