2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine → 7-(6-Chloropyridin-3-yl)-1-(2,5-dichlorobenzyl)-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine

Reaction equation

[Cl:1][c:2]1[c:3]([CH2:4][N:5]2[c:6]3[c:7]([n:11][cH:12][c:13]([I:15])[cH:14]3)[NH:8][CH2:9][CH2:10]2)[cH:16][c:17]([Cl:20])[cH:18][cH:19]1.[Cl:21][c:22]1[n:23][cH:24][c:25]([B:28]2[O:29][C:30]([CH3:31])([CH3:32])[C:33]([CH3:34])([CH3:35])[O:36]2)[cH:26][cH:27]1>>[Cl:1][c:2]1[c:3]([CH2:4][N:5]2[c:6]3[c:7]([n:11][cH:12][c:13](-[c:25]4[cH:24][n:23][c:22]([Cl:21])[cH:27][cH:26]4)[cH:14]3)[NH:8][CH2:9][CH2:10]2)[cH:16][c:17]([Cl:20])[cH:18][cH:19]1

Participants

Reactant 2

HCID 27947192-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

HCID 578860791-(2,5-Dichlorobenzyl)-7-iodo-3,4-dihydro-1H-pyrido[2,3-b]pyrazine

Product 1

HCID 578860757-(6-Chloropyridin-3-yl)-1-(2,5-dichlorobenzyl)-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine

Sources & evidence

ORD record: ord-5d16432c842342449ea5fb3612f0a0e1
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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