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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 30004Generated: October 23, 2026

2-Bromo-5-methoxybenzoic acid → 2-(2-Cyclopropylacetyl)-5-methoxybenzoic acid

https://huagongshe.com/en/reaction/30004

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Bromo-5-methoxybenzoic acidHCID 89906—
Reactant2-cyclopropyl-N-methoxy-N-methylacetamideHCID 22473766—
ReactantButyllithiumHCID 178418339—
Product2-(2-Cyclopropylacetyl)-5-methoxybenzoic acidHCID 69214469—

Reaction Steps

This compound is synthesized according to the method described in 3.2. by reacting 2-bromo-5-methoxybenzoic acid pretreated with n-butyllithium with 2-cyclopropyl-N-methoxy-N-methylacetamide. It is used in crude form in the following reaction.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07423030B2
Source datasetuspto-grants-2008_09
ORD IDord-96ff1326f46e4848968ef5851dc111d3
Source noteuspto-grants-2008_09