2-Bromo-5-methoxybenzoic acid → 2-(2-Cyclopropylacetyl)-5-methoxybenzoic acid

HRID 30004

Reaction equation

HRID 30004 reaction equation
Br[C:2]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].C([Li])CCC.[CH:18]1([CH2:21][C:22](N(OC)C)=[O:23])[CH2:20][CH2:19]1>>[CH:18]1([CH2:21][C:22]([C:2]2[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:3]=2[C:4]([OH:6])=[O:5])=[O:23])[CH2:20][CH2:19]1

Participants

4

Reactant 3

HCID 899062-Bromo-5-methoxybenzoic acidHCID 224737662-cyclopropyl-N-methoxy-N-methylacetamideHCID 178418339Butyllithium

Product 1

HCID 692144692-(2-Cyclopropylacetyl)-5-methoxybenzoic acid

Procedure

This compound is synthesized according to the method described in 3.2. by reacting 2-bromo-5-methoxybenzoic acid pretreated with n-butyllithium with 2-cyclopropyl-N-methoxy-N-methylacetamide. It is used in crude form in the following reaction.

Workup

  1. customThis compound is synthesized
  2. customin the following reaction

Sources & evidence

ORD record
ord-96ff1326f46e4848968ef5851dc111d3
Source dataset
uspto-grants-2008_09
Patent number
US07423030B2

Linked notes

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