2-Bromo-5-chlorobenzoic acid → 5-chloro-2-(4-methoxybenzoyl)benzoic Acid

HRID 30048Notes

Reaction equation

HRID 30048 reaction equation
Br[C:2]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].C([Li])CCC.[CH3:17][O:18][C:19]1[CH:30]=[CH:29][C:22]([C:23](N(OC)C)=[O:24])=[CH:21][CH:20]=1>>[Cl:11][C:8]1[CH:9]=[CH:10][C:2]([C:23](=[O:24])[C:22]2[CH:29]=[CH:30][C:19]([O:18][CH3:17])=[CH:20][CH:21]=2)=[C:3]([CH:7]=1)[C:4]([OH:6])=[O:5]

Participants

4

Reactant 3

HCID 890272-Bromo-5-chlorobenzoic acidHCID 15105748N,4-Dimethoxy-N-methylbenzamideHCID 178418339Butyllithium

Product 1

HCID 113807465-chloro-2-(4-methoxybenzoyl)benzoic Acid

Procedure

This compound is synthesized according to the method described in 3.2. by reacting 2-bromo-5-chlorobenzoic acid pretreated with n-butyllithium with 4-methoxy-N-methoxy-N-methyl-benzamide. It is used in crude form in the following reaction.

Workup

  1. customThis compound is synthesized
  2. customin the following reaction

Sources & evidence

ORD record
ord-6eb27124c1a34a0e8db0b4628617f14a
Source dataset
uspto-grants-2008_09
Patent number
US07423030B2

Reaction notes

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