4-Amino-1-Boc-piperidine → 4-[6-Amino-5-(2-fluoro-benzoyl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid tert-butyl ester

HRID 30106

Reaction equation

HRID 30106 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[F:16])=[O:9])=[CH:6][CH:5]=[C:4](Cl)[N:3]=1.[NH2:18][CH:19]1[CH2:24][CH2:23][N:22]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:21][CH2:20]1>>[C:28]([O:27][C:25]([N:22]1[CH2:23][CH2:24][CH:19]([NH:18][C:4]2[CH:5]=[CH:6][C:7]([C:8](=[O:9])[C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[F:16])=[C:2]([NH2:1])[N:3]=2)[CH2:20][CH2:21]1)=[O:26])([CH3:31])([CH3:29])[CH3:30]

Participants

3

Reactant 2

HCID 12682914-Amino-1-Boc-piperidineHCID 58590830(2-Amino-6-chloro-pyridin-3-yl)-(2-fluoro-phenyl)-methanone

Product 1

HCID 585908374-[6-Amino-5-(2-fluoro-benzoyl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid tert-butyl ester

Procedure

The title compound was prepared from (2-Amino-6-chloro-pyridin-3-yl)-(2-fluoro-phenyl)-methanone (Example 7) and 4-amino-1-N-Boc-piperidine (Astatech, >96%) using the procedure described in Step B, Example 6. HRMS, observed: 415.2143, Calcd for (M+H)+: 415.2140.

Sources & evidence

ORD record
ord-24b9ae238acc4a2d87ee58fb37f2cbeb
Source dataset
uspto-grants-2008_09
Patent number
US07423051B2

Linked notes

Loading…