Benzene, 1-iodo-3-methoxy- → (2-Amino-6-chloro-pyridin-3-yl)-(3-methoxy-phenyl)-methanone

HRID 30115

Reaction equation

HRID 30115 reaction equation
[NH2:1][C:2]1[N:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:3]=1[C:4](N(OC)C)=[O:5].I[C:16]1[CH:17]=[C:18]([O:22][CH3:23])[CH:19]=[CH:20][CH:21]=1>>[NH2:1][C:2]1[C:3]([C:4]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([O:22][CH3:23])[CH:17]=2)=[O:5])=[CH:10][CH:11]=[C:12]([Cl:14])[N:13]=1

Participants

3

Reactant 2

HCID 69839Benzene, 1-iodo-3-methoxy-HCID 585908242-Amino-6-chloro-N-methoxy-N-methyl-nicotinamide

Product 1

HCID 58590838(2-Amino-6-chloro-pyridin-3-yl)-(3-methoxy-phenyl)-methanone

Procedure

The title compound was prepared from 2-Amino-6-chloro-N-methoxy-N-methyl-nicotinamide (Example 3) and 3-iodoanisole (Aldrich) using the procedure described in Example 7. HRMS, observed: 262.0514, Calcd for M+: 262.0509.

Sources & evidence

ORD record
ord-f87a95db45314820a6268798c3eb645f
Source dataset
uspto-grants-2008_09
Patent number
US07423051B2

Linked notes

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