4-Amino-3-fluoropyridine → Isopropyl 4-(4-(3-fluoropyridin-4-ylamino)-6H-pyrimido[5,4-b][1,4]oxazin-8(7H)-yl)piperidine-1-carboxylate

HRID 301576

Reaction equation

HRID 301576 reaction equation
[Cl:9][c:10]1[n:11][cH:12][n:13][c:14]2[c:15]1[O:16][CH2:17][CH2:18][N:19]2[CH:20]1[CH2:21][CH2:22][N:23]([C:26](=[O:27])[O:28][CH:29]([CH3:30])[CH3:31])[CH2:24][CH2:25]1.[F:1][c:2]1[cH:3][n:4][cH:5][cH:6][c:7]1[NH2:8]>>[F:1][c:2]1[cH:3][n:4][cH:5][cH:6][c:7]1[NH:8][c:10]1[n:11][cH:12][n:13][c:14]2[c:15]1[O:16][CH2:17][CH2:18][N:19]2[CH:20]1[CH2:21][CH2:22][N:23]([C:26](=[O:27])[O:28][CH:29]([CH3:30])[CH3:31])[CH2:24][CH2:25]1

Participants

3

Reactant 2

HCID 8171224-Amino-3-fluoropyridineHCID 58293615isopropyl 4-(4-chloro-6H-pyrimido[5,4-b][1,4]oxazin-8(7H)-yl)piperidine-1-carboxylate

Product 1

HCID 58293646Isopropyl 4-(4-(3-fluoropyridin-4-ylamino)-6H-pyrimido[5,4-b][1,4]oxazin-8(7H)-yl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-824c4b09add04d5eae26802bd1f69df8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Linked notes

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