HCID 68839044, compound → 4,6-Dihydrothieno(3,4-c)furan-1,3-dione
Reaction equation
CO[C:3]([CH:5]1[CH2:9][S:8][CH2:7][C:6]1(O)[C:10]([OH:12])=[O:11])=[O:4]>C(OC(=O)C)(=O)C>[S:8]1[CH2:7][C:6]2[C:10]([O:12][C:3](=[O:4])[C:5]=2[CH2:9]1)=[O:11]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 3-hydroxy tetrahydro thiophene-3,4-dicarboxylicacid-4-methylester (2.87 g, 14.9 mmol) in acetic anhydride (20 ml) was refluxed for 4 h. The reaction mixture was filtered and concentrated under reduce pressure. The solid residue was triturated with acetone, dried with Na2SO4 and concentrated in vacuo. The solid product was recrystallized from benzene to give 2,5-dihydrothiophene-3,4-dicarboxylic anhydride in 26% yield.
Workup
- filtrationThe reaction mixture was filtered
- concentrationconcentrated
- customThe solid residue was triturated with acetone
- dry with materialdried with Na2SO4
- concentrationconcentrated in vacuo
- customThe solid product was recrystallized from benzene
Sources & evidence
- ORD record
- ord-c525aa781d6a4cd0ac56813da6847193
- Source dataset
- uspto-grants-2008_09
- Patent number
- US07423057B2
Reaction notes
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