Acetate → 6-(Spiro[4.5]dec-7-ylmethoxy)-pyridine-3-carboxaldehyde

HRID 302903

Reaction equation

HRID 302903 reaction equation
[Br:48][c:49]1[cH:50][cH:51][c:52]([CH:55]=[O:56])[cH:53][n:54]1.[C:1]([P:2]([C:3]([CH3:4])([CH3:5])[CH3:6])[c:7]1[cH:8][cH:9][c:10]2[c:11]([cH:12][cH:13][cH:14][cH:15]2)[c:16]1-[c:17]1[c:18]2[c:19]([cH:20][cH:21][cH:22][cH:23]2)[cH:24][cH:25][cH:26]1)([CH3:27])([CH3:28])[CH3:29].[C:30](=[O:31])([O-:32])[O-:33].[CH2:36]1[CH2:37][CH2:38][CH2:39][C:40]12[CH2:41][CH:42]([CH2:46][OH:47])[CH2:43][CH2:44][CH2:45]2.[CH3:66][c:67]1[cH:68][cH:69][cH:70][cH:71][cH:72]1.[Cs+:34].[Cs+:35].[O-:58][C:59]([CH3:60])=[O:61].[O-:62][C:63]([CH3:64])=[O:65].[Pd+2:57]>>[CH2:36]1[CH2:37][CH2:38][CH2:39][C:40]12[CH2:41][CH:42]([CH2:46][O:47][c:49]1[cH:50][cH:51][c:52]([CH:55]=[O:56])[cH:53][n:54]1)[CH2:43][CH2:44][CH2:45]2

Participants

9

Reactant 8

HCID 175Acetate2×HCID 1140TolueneHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 2734941(1,1'-Binaphthalen)-2-yldi-tert-butylphosphineHCID 117692346-Bromo-3-pyridinecarboxaldehydeHCID 57771578Spiro[4.5]dec-7-yl-methanol

Product 1

HCID 577714876-(Spiro[4.5]dec-7-ylmethoxy)-pyridine-3-carboxaldehyde

Sources & evidence

ORD record
ord-4cd88442e43b4480bfda4722b61a2e32
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Linked notes

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