Dichloromethane → 3-phenyl-3-[4-(7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propan-1-ol

HRID 303901

Reaction equation

HRID 303901 reaction equation
[CH2:2]([Al+:3][CH2:4][CH:5]([CH3:6])[CH3:7])[CH:8]([CH3:9])[CH3:10].[CH3:48][CH2:49][CH2:50][CH2:51][CH2:52][CH3:53].[Cl:45][CH2:46][Cl:47].[H-:1].[c:11]1([CH:17]([CH2:18][C:19](=[O:20])[O:21][CH3:22])[n:23]2[n:24][cH:25][c:26](-[c:28]3[c:29]4[c:30]([n:31][cH:32][n:33]3)[n:34]([CH2:37][O:38][CH2:39][CH2:40][Si:41]([CH3:42])([CH3:43])[CH3:44])[cH:35][cH:36]4)[cH:27]2)[cH:12][cH:13][cH:14][cH:15][cH:16]1>>[c:11]1([CH:17]([CH2:18][CH2:19][OH:20])[n:23]2[n:24][cH:25][c:26](-[c:28]3[c:29]4[c:30]([n:31][cH:32][n:33]3)[n:34]([CH2:37][O:38][CH2:39][CH2:40][Si:41]([CH3:42])([CH3:43])[CH3:44])[cH:35][cH:36]4)[cH:27]2)[cH:12][cH:13][cH:14][cH:15][cH:16]1

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 8058HexaneHCID 166653HydrideHCID 16686348Bis(2-methylpropyl)alumanyliumHCID 57477997methyl 3-phenyl-3-[4-(7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-propanoate

Product 1

HCID 574779983-phenyl-3-[4-(7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propan-1-ol

Sources & evidence

ORD record
ord-38686ea1ef324a028dc26d78acc28d11
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Linked notes

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