HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Malonate → HCID 178418389, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Malonate | HCID 7761 | — |
| Reactant | Acetamidine monohydrochloride | HCID 67170 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 4,6-Dihydroxy-2-methylpyrimidinamine | HCID 178418345 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178418389 | HCID 178418389 | — |
Reaction Steps
The first intermediate, 4,6-dihydroxy-2-methylpyrimidinamine, is synthesized by preparing sodium ethoxide in situ from sodium and an hydrous ethanol under a nitrogen blanket. Acetamidine hydrochloride and diethyl malonate are added and the reaction mixture heated to boiling for 2 to 5 hours to afford 4,6-dihydroxy-2-methylpyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05732717 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-4d14267579d347aaab5da8765031fa8d |
| Source note | uspto-grants-1998_03 |