Toluene → tert-Butyl 8-(isoquinolin-6-yl)-2,8-diazaspiro[4.5]decane-2-carboxylate

HRID 304813

Reaction equation

HRID 304813 reaction equation
[Br:18][c:19]1[cH:20][c:21]2[cH:22][cH:23][n:24][cH:25][c:26]2[cH:27][cH:28]1.[CH2:1]1[N:2]([C:11](=[O:12])[O:13][C:14]([CH3:15])([CH3:16])[CH3:17])[CH2:3][CH2:4][C:5]12[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]2.[CH3:75][c:76]1[cH:77][cH:78][cH:79][cH:80][cH:81]1.[cH:29]1[cH:30][cH:31][c:32]([P:33]([c:34]2[cH:35][cH:36][c:37]3[c:38]([cH:39][cH:40][cH:41][cH:42]3)[c:43]2-[c:44]2[c:45]3[c:46]([cH:47][cH:48][cH:49][cH:50]3)[cH:51][cH:52][c:53]2[P:54]([c:55]2[cH:56][cH:57][cH:58][cH:59][cH:60]2)[c:61]2[cH:62][cH:63][cH:64][cH:65][cH:66]2)[c:67]2[cH:68][cH:69][cH:70][cH:71][cH:72]2)[cH:73][cH:74]1>>[CH2:1]1[N:2]([C:11](=[O:12])[O:13][C:14]([CH3:15])([CH3:16])[CH3:17])[CH2:3][CH2:4][C:5]12[CH2:6][CH2:7][N:8]([c:19]1[cH:20][c:21]3[cH:22][cH:23][n:24][cH:25][c:26]3[cH:27][cH:28]1)[CH2:9][CH2:10]2

Participants

5

Reactant 4

HCID 1140TolueneHCID 3136816-BromoisoquinolineHCID 634876Binap, (A+-)-HCID 34178604tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate

Product 1

HCID 66700964tert-Butyl 8-(isoquinolin-6-yl)-2,8-diazaspiro[4.5]decane-2-carboxylate

Sources & evidence

ORD record
ord-0672463d9e1b45cb8471c15d998cfaa0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Linked notes

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