Methanol → 4-Methoxy-7-(phenylmethyl)-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

Reaction equation

[CH3:23][O-:24].[CH3:26][OH:27].[Cl:1][c:2]1[c:3]2[c:4]([n:5][c:6]([C:8]([F:9])([F:10])[F:11])[n:7]1)[CH2:12][N:13]([CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[CH2:14][CH2:15]2.[Na+:25]>>[c:2]1([O:24][CH3:23])[c:3]2[c:4]([n:5][c:6]([C:8]([F:9])([F:10])[F:11])[n:7]1)[CH2:12][N:13]([CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[CH2:14][CH2:15]2

Participants

Reactant 4

HCID 887Methanol

HCID 923Sodium Ion

HCID 3826051Methoxide

HCID 184565217-Benzyl-4-chloro-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-D]pyrimidine

Product 1

HCID 184565234-Methoxy-7-(phenylmethyl)-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

Sources & evidence

ORD record: ord-400e71afed6b4a119b7af1dd9f44cf3b
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

Reaction notes

Loading…