7-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid → 7-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [2-chloro-5-(2-dimethylamino-ethylsulfamoyl)-thiophen-3-yl]-amide

Reaction equation

[CH3:26][N:27]([CH2:28][CH2:29][NH:30][S:31](=[O:32])(=[O:33])[c:34]1[s:35][c:36]([Cl:40])[c:37]([NH2:39])[cH:38]1)[CH3:41].[F:1][CH:2]([c:3]1[cH:4][c:5](-[c:15]2[cH:16][cH:17][c:18]([C:21]([F:22])([F:23])[F:24])[cH:19][cH:20]2)[n:6][c:7]2[n:8]1[n:9][cH:10][c:11]2[C:12](=[O:13])[OH:14])[F:25]>>[F:1][CH:2]([c:3]1[cH:4][c:5](-[c:15]2[cH:16][cH:17][c:18]([C:21]([F:22])([F:23])[F:24])[cH:19][cH:20]2)[n:6][c:7]2[n:8]1[n:9][cH:10][c:11]2[C:12](=[O:13])[NH:39][c:37]1[c:36]([Cl:40])[s:35][c:34]([S:31]([NH:30][CH2:29][CH2:28][N:27]([CH3:26])[CH3:41])(=[O:32])=[O:33])[cH:38]1)[F:25]