HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 30804Generated: October 26, 2026
Dimethylformamide → 1-Methylpiperidine-4-carbonyl chloride
https://huagongshe.com/reaction/30804
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 1-Methylpiperidine-4-carboxylic acid | HCID 2736939 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Methylpiperidine-4-carbonyl chloride | HCID 436503 | — |
Reaction Steps
A flask was flame dried and placed under a nitrogen atmosphere. 1-methylpiperidine-4-carboxylic acid (1 eq) in anhydrous methylene chloride added to flask and cooled to 20° C. in a water bath. Dimethylformamide added, then oxalyl chloride (1.4 eq) in methylene chloride. Reaction refluxed for 2 hours, brought to room temperature, concentrated and azeotroped with toluene to yield 1-methylpiperidine-4-carbonyl chloride as a light yellow fluffy solid. MS: MH+=162.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07423150B2 |
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| Source dataset | uspto-grants-2008_09 |
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| ORD ID | ord-fa13b4bfb2d4459d835da3c9b478d77a |
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| Source note | uspto-grants-2008_09 |
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