Dichloromethane → 8-Chloro-3-(chloromethyl)-2-(2-trifluoromethylphenyl)quinoline

Reaction equation

[Cl:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[cH:7][c:8]([CH2:22][OH:23])[c:9](-[c:12]3[c:13]([C:18]([F:19])([F:20])[F:21])[cH:14][cH:15][cH:16][cH:17]3)[n:10][c:11]12.[Cl:28][CH2:29][Cl:30].[S:24]([Cl:25])([Cl:26])=[O:27]>>[Cl:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[cH:7][c:8]([CH2:22][Cl:26])[c:9](-[c:12]3[c:13]([C:18]([F:19])([F:20])[F:21])[cH:14][cH:15][cH:16][cH:17]3)[n:10][c:11]12

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 24386Thionyl Chloride

HCID 57556184(8-Chloro-2-(2-trifluoromethylphenyl)quinolin-3-yl)methanol

Product 1

HCID 575561498-Chloro-3-(chloromethyl)-2-(2-trifluoromethylphenyl)quinoline

Sources & evidence

ORD record: ord-fe641d3318d14156887e34fd4ca1cffc
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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