2-[2-(5-Fluoro-2-methoxyphenyl)-2-methylpropyl]-2-trifluoromethyloxirane → Ethyl 3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoro methyl)pentyl]amino}-1h-indazol-1-yl)benzoate

HRID 309954

Reaction equation

HRID 309954 reaction equation
[F:1][c:2]1[cH:3][cH:4][c:5]([O:19][CH3:20])[c:6]([C:8]([CH2:9][C:10]2([C:13]([F:14])([F:15])[F:16])[O:11][CH2:12]2)([CH3:17])[CH3:18])[cH:7]1.[NH2:21][c:22]1[c:23]2[cH:24][n:25][n:26](-[c:31]3[cH:32][c:33]([C:34](=[O:35])[O:36][CH2:37][CH3:38])[cH:39][cH:40][cH:41]3)[c:27]2[cH:28][cH:29][cH:30]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([O:19][CH3:20])[c:6]([C:8]([CH2:9][C:10]([OH:11])([CH2:12][NH:21][c:22]2[c:23]3[cH:24][n:25][n:26](-[c:31]4[cH:32][c:33]([C:34](=[O:35])[O:36][CH2:37][CH3:38])[cH:39][cH:40][cH:41]4)[c:27]3[cH:28][cH:29][cH:30]2)[C:13]([F:14])([F:15])[F:16])([CH3:17])[CH3:18])[cH:7]1

Participants

3

Reactant 2

HCID 160992392-[2-(5-Fluoro-2-methoxyphenyl)-2-methylpropyl]-2-trifluoromethyloxiraneHCID 57615935Ethyl 3-(4-amino-1H-indazol-1-yl)benzoate

Product 1

HCID 57615933Ethyl 3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoro methyl)pentyl]amino}-1h-indazol-1-yl)benzoate

Sources & evidence

ORD record
ord-c99b90d35e4940858cd548b64370f606
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Linked notes

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