2,2,3,3,3-Pentafluoropropylamine → 2-Ethoxy-N-[(S)-5-(2-hydroxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-N'-(2,2,3,3,3-pentafluoro-propyl)-malonamide

Participants

Role	Name	HCID	Charge
Reactant	2,2,3,3,3-Pentafluoropropylamine	HCID 79002	—
Reactant	N-[(S)-5-(2-Benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-ethoxy-N'-(2,2,3,3,3-pentafluoro-propyl)-malonamide	HCID 58972527	—
Product	2-Ethoxy-N-[(S)-5-(2-hydroxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-N'-(2,2,3,3,3-pentafluoro-propyl)-malonamide	HCID 24876784	—

Reaction Steps

Using N—[(S)-5-(2-benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-ethoxy-N′-(2,2,3,3,3-pentafluoro-propyl)-malonamide and 2,2,3,3,3-pentafluoropropylamine, the title compound was prepared in the same manner as described for example 3. White solid (83%). MS: m/e=530(M+H+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07425551B2
Source dataset	uspto-grants-2008_09
ORD ID	ord-f194d77d882e4395a0e54ec5a58ba580
Source note	uspto-grants-2008_09