7-Hydroxyisoflavone → 3-Phenylchroman-7-ol

HRID 31310

Reaction equation

HRID 31310 reaction equation
F[C:2]1[CH:3]=[C:4]([CH:8]2[CH2:17][C:16]3[C:11](=[CH:12][C:13]([OH:18])=[CH:14][CH:15]=3)[O:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1.OC1C=C2C(C(=O)C(C3C=CC=CC=3)=CO2)=CC=1>>[C:4]1([CH:8]2[CH2:17][C:16]3[C:11](=[CH:12][C:13]([OH:18])=[CH:14][CH:15]=3)[O:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=[CH:2][CH:3]=1

Participants

3

Reactant 2

HCID 53768917-HydroxyisoflavoneHCID 179784803-(3-Fluorophenyl)chroman-7-ol

Product 1

HCID 204967613-Phenylchroman-7-ol

Procedure

3-Phenylchroman-7-ol was prepared as described for 3-(3-fluorophenyl)-chroman-7-ol in Example 81(d) using 0.5 g of 7-hydroxy-3-phenylchromen-4-one. 1H NMR (400 MHz, d6-DMSO) δ: 8.18 (br s, 1H), 7.31-7.34 (m, 4H), 7.25-7.27 (m, 1H), 6.88 (d, 1H, J 8.2 Hz), 6.30 (dd, 1H, J 8.2, 2.4 Hz), 6.20 (d, 1H, J 2.4 Hz), 4.21 (dd, 1H, J 10.3, 3.6 Hz), 4.00 (t, 1H, 10.3 Hz), 3.13 (m, 1H), 2.84-2.87 (m, 2H).

Sources & evidence

ORD record
ord-9894a538d997468592883b1d4853972b
Source dataset
uspto-grants-2008_09
Patent number
US07425568B2

Linked notes

Loading…