Dichloromethane → N-Trifluoroacetyl-8-bromo-7-hydroxy-1-isopropyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Reaction equation

[B:24]([Br:25])([Br:26])[Br:27].[Cl:28][CH2:29][Cl:30].[F:1][C:2]([C:3](=[O:4])[N:5]1[CH2:6][CH2:7][c:8]2[c:9]([cH:15][c:16]([Br:21])[c:17]([O:19][CH3:20])[cH:18]2)[CH:10]([CH:12]([CH3:13])[CH3:14])[CH2:11]1)([F:22])[F:23]>>[F:1][C:2]([C:3](=[O:4])[N:5]1[CH2:6][CH2:7][c:8]2[c:9]([cH:15][c:16]([Br:21])[c:17]([OH:19])[cH:18]2)[CH:10]([CH:12]([CH3:13])[CH3:14])[CH2:11]1)([F:22])[F:23]

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 25134Boron tribromide

HCID 22292805N-trifluoroacetyl-8-bromo-1-isopropyl-7-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine

Product 1

HCID 22292823N-Trifluoroacetyl-8-bromo-7-hydroxy-1-isopropyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Sources & evidence

ORD record: ord-6f6a8b8e7d1f4c5e868a67334fc3cd24
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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