HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Sulfate → 2-Bromophenetole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Sulfate | HCID 6163 | — |
| Reactant | 2-Bromophenol | HCID 7244 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 2-Bromophenetole | HCID 68500 | — |
Reaction Steps
A mixture of 17.5 g of 2-bromophenol, 66 ml of diethyl sulphate and 170 ml of 10% NaOH solution is refluxed for 2 hours. After cooling the reaction mixture to RT, it is extracted with EtOAc, the organic phase is washed with 2N NaOH solution and dried over Na2SO4, and the solvent is evaporated off under vacuum. 19.6 g of the expected product are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07425566B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-7430bb1eac354422a753a5f7420cbe7a |
| Source note | uspto-grants-2008_09 |