Sodium Ion → 1-[3-Bromo-5-(trifluoromethyl)phenyl]pyrrolidin-3-ol

Reaction equation

[Br:13][CH2:14][CH:15]([CH2:16][CH2:17][Br:18])[OH:19].[Br:1][c:2]1[cH:3][c:4]([NH2:5])[cH:6][c:7]([C:9]([F:10])([F:11])[F:12])[cH:8]1.[Na+:20].[Na+:21].[O-:22][C:23](=[O:24])[O-:25]>>[Br:1][c:2]1[cH:3][c:4]([N:5]2[CH2:14][CH:15]([OH:19])[CH2:16][CH2:17]2)[cH:6][c:7]([C:9]([F:10])([F:11])[F:12])[cH:8]1

Participants

Reactant 4

HCID 923Sodium Ion2×

HCID 19660Carbonate Ion

HCID 295701,4-Dibromo-2-butanol

HCID 27358803-Bromo-5-(trifluoromethyl)aniline

Product 1

HCID 670223731-[3-Bromo-5-(trifluoromethyl)phenyl]pyrrolidin-3-ol

Sources & evidence

ORD record: ord-873fdcbd5a434f56b49804b904cf243d
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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