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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 31461Generated: October 27, 2026

2-(4-Iodophenyl)-5-methyl-[1,3,4]oxadiazole → Thiophene-3-carboxylic acid[6-methyl-4'-(5-methyl-[1,3,4]oxadiazol-2-yl)-biphenyl-3-yl]-amide

https://huagongshe.com/reaction/31461

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(4-Iodophenyl)-5-methyl-[1,3,4]oxadiazoleHCID 676569—
ReactantN-[4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-3-thiophenecarboxamideHCID 21914662—
SolventIsopropanolHCID 3776—
ProductThiophene-3-carboxylic acid[6-methyl-4'-(5-methyl-[1,3,4]oxadiazol-2-yl)-biphenyl-3-yl]-amideHCID 58629794—

Reaction Steps

Example 34 was prepared using 2-(4-iodophenyl)-5-methyl-[1,3,4]oxadiazole (Intermediate 15) and N-[4-methyl-3-(4,4,5,5, -tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]thiophene-3-amide (Intermediate 27) with propan-2-ol as the solvent.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07425555B2
Source datasetuspto-grants-2008_09
ORD IDord-a1347c86e2fb4e1fb11912cdbd0957d3
Source noteuspto-grants-2008_09