Methyl triflate → 4-(2-Methyl-imidazole-1-sulfonyl)-piperazine-1-carboxylic acid tert-butyl ester triflate salt

HRID 31510

Reaction equation

HRID 31510 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([S:14]([N:17]2[CH:21]=[CH:20][N:19]=[C:18]2[CH3:22])(=[O:16])=[O:15])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C[O:24][S:25]([C:28]([F:31])([F:30])[F:29])(=[O:27])=[O:26]>C(Cl)Cl>[OH:27][S:25]([C:28]([F:31])([F:30])[F:29])(=[O:26])=[O:24].[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([S:14]([N:17]2[CH:21]=[CH:20][N:19]=[C:18]2[CH3:22])(=[O:16])=[O:15])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 9526Methyl triflateHCID 692737584-(2-Methyl-imidazole-1-sulfonyl)-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 865955274-(2-Methyl-imidazole-1-sulfonyl)-piperazine-1-carboxylic acid tert-butyl ester triflate salt

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 4-(2-methyl-imidazole-1-sulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (1.4 g, 4.24 mmol) in methylene chloride was cooled in an ice bath, and trifluoromethanesulfonic acid methyl ester (0.56 mL, 4.9 mmol) was added via a pipet. After stirring at ice temperature for 3 h, the solvent was evaporated to give 4-(2-methyl-imidazole-1-sulfonyl)-piperazine-1-carboxylic acid tert-butyl ester triflate salt as yellow solids.

Workup

  1. customthe solvent was evaporated

Sources & evidence

ORD record
ord-38fad87017304b2ea8cf82845de81665
Source dataset
uspto-grants-2008_09
Patent number
US07425638B2

Linked notes

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