2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 2-{[6-(1-Cyanocyclopropyl)pyridin-2-yl]amino}-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

HRID 315867

Reaction equation

HRID 315867 reaction equation
[Br:1][c:2]1[cH:3][cH:4][cH:5][c:6]([C:8]2([C:11]#[N:12])[CH2:9][CH2:10]2)[n:7]1.[NH2:13][c:14]1[s:15][c:16](-[c:22]2[c:23]([F:33])[cH:24][c:25]([C:29]([CH3:30])([CH3:31])[OH:32])[cH:26][c:27]2[F:28])[cH:17][c:18]1[C:19](=[O:20])[NH2:21]>>[c:2]1([NH:13][c:14]2[s:15][c:16](-[c:22]3[c:23]([F:33])[cH:24][c:25]([C:29]([CH3:30])([CH3:31])[OH:32])[cH:26][c:27]3[F:28])[cH:17][c:18]2[C:19](=[O:20])[NH2:21])[cH:3][cH:4][cH:5][c:6]([C:8]2([C:11]#[N:12])[CH2:9][CH2:10]2)[n:7]1

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 595256751-(6-Bromopyridin-2-YL)cyclopropanecarbonitrile

Product 1

HCID 595255722-{[6-(1-Cyanocyclopropyl)pyridin-2-yl]amino}-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Sources & evidence

ORD record
ord-46f1fb8ff6bd4236aa83841f8e2221e0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Linked notes

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