1-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → 1-Cyclopropyl-7-[3-[(cyclopropylamino)methyl]-4-fluoropyrrolidin-1-yl]-6,8-difluoro-4-oxoquinoline-3-carboxylic acid

HRID 316203

Reaction equation

HRID 316203 reaction equation
[CH:1]1([n:4]2[cH:5][c:6]([C:18](=[O:19])[OH:20])[c:7](=[O:17])[c:8]3[cH:9][c:10]([F:16])[c:11]([F:15])[c:12]([F:14])[c:13]23)[CH2:2][CH2:3]1.[CH:21]1([NH:24][CH2:25][CH:26]2[CH2:27][NH:28][CH2:29][CH:30]2[F:31])[CH2:22][CH2:23]1>>[CH:1]1([n:4]2[cH:5][c:6]([C:18](=[O:19])[OH:20])[c:7](=[O:17])[c:8]3[cH:9][c:10]([F:16])[c:11]([N:28]4[CH2:27][CH:26]([CH2:25][NH:24][CH:21]5[CH2:22][CH2:23]5)[CH:30]([F:31])[CH2:29]4)[c:12]([F:14])[c:13]23)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 5354141-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acidHCID 230620733-Pyrrolidinemethanamine,N-cyclopropyl-4-fluoro-,(3R,4S)-(9CI)

Product 1

HCID 231256551-Cyclopropyl-7-[3-[(cyclopropylamino)methyl]-4-fluoropyrrolidin-1-yl]-6,8-difluoro-4-oxoquinoline-3-carboxylic acid

Sources & evidence

ORD record
ord-a88e9970e4be4012b815e96b085847f1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Linked notes

Loading…