1,5-Dioxaspiro[5.5]undec-3-ylmethanol → 2-(((4-(1,5-Dioxaspiro[5.5]undec-3-ylmethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

HRID 31634

Reaction equation

HRID 31634 reaction equation
[Na:1].CO[CH:4]1[O:9][CH2:8][CH:7]([CH2:10][O:11][C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH2:18][S:19]([C:21]3[NH:25][C:24]4[CH:26]=[CH:27][CH:28]=[CH:29][C:23]=4[N:22]=3)=[O:20])[C:13]=2[CH3:30])[CH2:6][O:5]1.O1[C:36]2([CH2:41][CH2:40]C[CH2:38][CH2:37]2)OCC(CO)C1>>[Na:1].[O:9]1[C:4]2([CH2:40][CH2:41][CH2:36][CH2:37][CH2:38]2)[O:5][CH2:6][CH:7]([CH2:10][O:11][C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH2:18][S:19]([C:21]3[NH:25][C:24]4[CH:26]=[CH:27][CH:28]=[CH:29][C:23]=4[N:22]=3)=[O:20])[C:13]=2[CH3:30])[CH2:8]1

Participants

3

Reactant 2

HCID 152866931,5-Dioxaspiro[5.5]undec-3-ylmethanolHCID 667760022-(((4-((2-Methoxy-1,3-dioxan-5-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

Product 1

HCID 667761042-(((4-(1,5-Dioxaspiro[5.5]undec-3-ylmethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium saltYield 8.4%

Procedure

The same procedure as in the steps (6b) to (6f) of Example 6 was repeated using 1,5-dioxaspiro[5.5]undec-3-ylmethanol obtained in the step (25a) to obtain the title compound (125 mg, total yield: 8.4%) as a light yellow solid.

Workup

  1. customobtained in the step (25a)

Sources & evidence

ORD record
ord-0a3e81c78d194ef582f33088c3b45e53
Source dataset
uspto-grants-2008_09
Patent number
US07425634B2

Linked notes

Loading…