(2-Methyl-1,3-dioxan-2-yl)methanol → 2-(((3-Methyl-4-((2-methyl-1,3-dioxan-2-yl)methoxy)pyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

HRID 31644

Reaction equation

HRID 31644 reaction equation
[Na:1].COC1OCC([CH2:10][O:11][C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH2:18][S:19]([C:21]3[NH:25][C:24]4[CH:26]=[CH:27][CH:28]=[CH:29][C:23]=4[N:22]=3)=[O:20])[C:13]=2[CH3:30])CO1.[CH3:31][C:32]1(CO)[O:37][CH2:36][CH2:35][CH2:34][O:33]1>>[Na:1].[CH3:30][C:13]1[C:14]([CH2:18][S:19]([C:21]2[NH:22][C:23]3[CH:29]=[CH:28][CH:27]=[CH:26][C:24]=3[N:25]=2)=[O:20])=[N:15][CH:16]=[CH:17][C:12]=1[O:11][CH2:10][C:32]1([CH3:31])[O:37][CH2:36][CH2:35][CH2:34][O:33]1

Participants

3

Reactant 2

HCID 59792415(2-Methyl-1,3-dioxan-2-yl)methanolHCID 667760022-(((4-((2-Methoxy-1,3-dioxan-5-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

Product 1

HCID 667764872-(((3-Methyl-4-((2-methyl-1,3-dioxan-2-yl)methoxy)pyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium saltYield 8.6%

Procedure

The same procedure as in the steps (6b) to (6f) of Example 6 was repeated using (2-methyl-1,3-dioxan-2-yl)methanol obtained in the step (33a) to obtain the title compound (220 mg, total yield: 8.6%) as a light yellow solid.

Workup

  1. customobtained in the step (33a)

Sources & evidence

ORD record
ord-531f6213a42b42b79ed7b0021e4b3883
Source dataset
uspto-grants-2008_09
Patent number
US07425634B2

Linked notes

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