1,1-Dihydroxypropan-2-one → (2-(Fluoromethyl)-1,3-dioxolan-2-yl)methanol
Reaction equation
[F:1][CH2:2][C:3]1([CH2:9][OH:10])[O:8][CH2:7][CH2:6]C[O:4]1.OC(O)C(=O)C>C(O)CO>[F:1][CH2:2][C:3]1([CH2:9][OH:10])[O:4][CH2:6][CH2:7][O:8]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
The same procedure as in the steps (44a) to (44c) using dihydroxyacetone except that ethylene glycol was used instead of 1,3-propanediol used in Example 44 to obtain the title compound (543 mg, total yield: 13.8%).
Sources & evidence
- ORD record
- ord-f98455c64b9644ab80c79cf17a2f0845
- Source dataset
- uspto-grants-2008_09
- Patent number
- US07425634B2
Reaction notes
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