HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 31721Generated: October 23, 2026
Nitric Acid → 4-Nitro-2,3,5-trimethylpyridine, 1-oxide
https://huagongshe.com/en/reaction/31721
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Ammonium Bicarbonate | HCID 14013 | — |
| Reactant | 2,3,5-Trimethyl-1-oxidopyridin-1-ium | HCID 10486907 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Nitro-2,3,5-trimethylpyridine, 1-oxide | HCID 11217611 | 81.5% |
Reaction Steps
To 98% sulfuric acid (4.93 kg, 49.3 mol), 2,3,5-trimethylpyridine1-oxide (1.38 kg, 10.1 mol) was added. After 97% nitric acid (1.44 kg) was added dropwise thereto over 50 minutes, the mixture was heated at 85° C. for 4 hours. The reaction mixture was poured to a mixture of ammonium hydrogen carbonate (10.6 kg) and water (9.0 L). The mixture was extracted with ethyl acetate (3.0 L×3). The obtained organic layer was concentrated and dried under vacuum overnight to obtain a desired product (1.50 kg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07425634B2 |
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| Source dataset | uspto-grants-2008_09 |
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| ORD ID | ord-96c5b1cc39524b49a713b86ca5077f65 |
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| Source note | uspto-grants-2008_09 |
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