2-Imidazoline → 1-(4-Ethylphenyl)-2-imidazolylethan-1-one

HRID 31779

Reaction equation

HRID 31779 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH3:12])=[CH:7][CH:6]=1)=[O:4].[NH:13]1[CH2:17][CH2:16][N:15]=[CH:14]1>C(#N)C>[CH2:11]([C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][C:14]2[NH:13][CH:17]=[CH:16][N:15]=2)=[CH:6][CH:7]=1)[CH3:12]

Participants

4

Reactant 2

HCID 681562-ImidazolineHCID 124019512-Bromo-1-(4-ethylphenyl)ethan-1-one

Product 1

HCID 221425781-(4-Ethylphenyl)-2-imidazolylethan-1-one

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

1 mmol of 2-bromo-1-(4-ethylphenyl)ethan-1-one in acetonitrile was added drop wise to 5.5 mmol imidazoline in acetonitrile at room temperature for fourteen hours. The reaction mixture was concentrated in vacuo and diluted with water and ethyl acetate. The solution was extracted three times with ethyl acetate and dried over sodium sulfate to obtain 1-(4-ethylphenyl)-2-imidazolylethan-1-one.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. additiondiluted with water and ethyl acetate
  3. extractionThe solution was extracted three times with ethyl acetate
  4. dry with materialdried over sodium sulfate

Sources & evidence

ORD record
ord-24ee89c2f0684d92a2fe9090065cfceb
Source dataset
uspto-grants-2008_09
Patent number
US07425557B2

Linked notes

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