4-(Trifluoromethyl)benzoyl chloride → 6-{[2-({5-Imidazol-2-yl-4-[4-(trifluoromethyl)phenyl]pyrimidin-2-yl}amino)ethyl]-amino}pyridine-3-carbonitrile

HRID 31876

Reaction equation

HRID 31876 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:11]=[CH:10][C:6]([C:7](Cl)=O)=[CH:5][CH:4]=1.Cl[C:15]1[CH:20]=[CH:19][C:18]([C:21]#[N:22])=[CH:17][N:16]=1.ClC1C=C(Cl)C=CC=1C1[C:36]([C:37]2[NH:38][CH:39]=[CH:40][N:41]=2)=[CH:35][N:34]=[C:33]([NH:42][CH2:43][CH2:44][NH:45]C2C=CC([N+]([O-])=O)=CN=2)[N:32]=1>>[NH:38]1[CH:39]=[CH:40][N:41]=[C:37]1[C:36]1[C:7]([C:6]2[CH:10]=[CH:11][C:3]([C:2]([F:13])([F:12])[F:1])=[CH:4][CH:5]=2)=[N:32][C:33]([NH:42][CH2:43][CH2:44][NH:45][C:15]2[N:16]=[CH:17][C:18]([C:21]#[N:22])=[CH:19][CH:20]=2)=[N:34][CH:35]=1

Participants

4

Reactant 3

HCID 676074-(Trifluoromethyl)benzoyl chlorideHCID 51520946-Chloro-3-pyridinecarbonitrileHCID 9847557Chir-98023

Product 1

HCID 221424936-{[2-({5-Imidazol-2-yl-4-[4-(trifluoromethyl)phenyl]pyrimidin-2-yl}amino)ethyl]-amino}pyridine-3-carbonitrile

Procedure

b 6-{[2-({5-imidazol-2-yl-4-[4-(trifluoromethyl)phenyl]pyrimidin-2-yl}amino)ethyl]-amino}pyridine-3-carbonitrile was prepared from 4-(trifluoromethyl)benzoyl chloride and 2-chloro-5-(cyano)pyridine using the general method for [4-(2,4-dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine.

Sources & evidence

ORD record
ord-5644389144a8421785b01900d6826ba8
Source dataset
uspto-grants-2008_09
Patent number
US07425557B2

Linked notes

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