4-Fluoro-2-(trifluoromethyl)benzoyl chloride → 6-{[2-({4-[4-Fluoro-2-(trifluoromethyl)phenyl]-5-imidazol-2-ylpyrimidin-2-yl}amino)ethyl]amino}pyridine-3-carbonitrile

HRID 31890

Reaction equation

HRID 31890 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=O)=[C:4]([C:11]([F:14])([F:13])[F:12])[CH:3]=1.Cl[C:16]1[CH:21]=[CH:20][C:19]([C:22]#[N:23])=[CH:18][N:17]=1.ClC1C=C(Cl)C=CC=1C1[C:37]([C:38]2[NH:39][CH:40]=[CH:41][N:42]=2)=[CH:36][N:35]=[C:34]([NH:43][CH2:44][CH2:45][NH:46]C2C=CC([N+]([O-])=O)=CN=2)[N:33]=1>>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]2[C:37]([C:38]3[NH:39][CH:40]=[CH:41][N:42]=3)=[CH:36][N:35]=[C:34]([NH:43][CH2:44][CH2:45][NH:46][C:16]3[N:17]=[CH:18][C:19]([C:22]#[N:23])=[CH:20][CH:21]=3)[N:33]=2)=[C:4]([C:11]([F:14])([F:13])[F:12])[CH:3]=1

Participants

4

Reactant 3

HCID 6056804-Fluoro-2-(trifluoromethyl)benzoyl chlorideHCID 51520946-Chloro-3-pyridinecarbonitrileHCID 9847557Chir-98023

Product 1

HCID 221430886-{[2-({4-[4-Fluoro-2-(trifluoromethyl)phenyl]-5-imidazol-2-ylpyrimidin-2-yl}amino)ethyl]amino}pyridine-3-carbonitrile

Procedure

6-{[2-({4-[4-fluoro-2-(trifluoromethyl)phenyl]-5-imidazol-2-ylpyrimidin-2-yl}amino)ethyl]amino}pyridine-3-carbonitrile was prepared from 4-fluoro-2-(trifluoromethyl)benzoyl chloride and 2-chloro-5-(cyano)pyridine using the general method for [4-(2,4-dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine.

Sources & evidence

ORD record
ord-b7597be2bc6c4cdcbeb2cd08a6838035
Source dataset
uspto-grants-2008_09
Patent number
US07425557B2

Linked notes

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